Diterpenoid Alkaloids in the Roots of Aconitum Bulleyanum Diels / 中国药师
China Pharmacist
;
(12): 1525-1528, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-607294
ABSTRACT
Objective:
To study the chemical constituents in the roots of Aconitum bulleyanum Diels.Methods:
The air-dried roots of A. bulleyanum were powdered and extracted by methanol with percolation. After removing the solvent under reduced pressure, the crude extract was dissolved in 1. 5% HCl solution, and then basified to pH 9 by NaOH (5%) and extracted by ethyl acetate to ob-tain crude alkaloidal extract after ethyl acetate removal. The alkaloidal extract was isolated and purified by column chromatography, and their structures were identified based on spectral analysis ( 1 H-NMR, 13 C-NMR, MS) .Results:
Totally 12 diterpenoid alkaloids were isolated from A. bulleyanum and characterized as foresaconitine (1), crassicauline A (2), chasmanine (3), talatisamine (4), 14-debenzoyl-franchetine (5), pengshenine A (6), crassicautine (7), yunaconitine (8), franchetine (9), liljestrandisine (10), transconitine B (11) and pseudoaconine (12).Conclusion:
Compounds 3-7, 10-12 are isolated from this plant for the first time.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacist
Year:
2017
Type:
Article
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