Effect of HPA gene polymorphism and its alleles on platelet transfusion / 中国输血杂志

ABSTRACT

Objective To investigate the effect of HPA gene polymorphism and its alleles on platelet transfusion.Methods From January 2015 to January 2017,50 patients suffered from Platelet transfusion refractoriness were collected as an observation group while 50 patients without Platelet transfusion refractoriness were collected as a control group.The HPA gene polymorphism of the both groups were compared.Results When compared with the control group,the HPA type coincidence rate of Donor and recipient in the observation group decreased significantly (4.00％ vs.82.00％,P =0.000).And patients in the observation group got decreased levels of percent platelet recovery and platelet corrected growth index.(HPA16,9,15) were common in both groups.However,aa,ab and bb of the HPA-2 allele got 37,8 and 5 cases in the observation group,while there were 48,2 and 0 cases in the control group (P=0.007).And aa,ab and bb of the HPA-3 allele got 33,9 and 8 cases in the observation group,while there were 46,3 and 1 cases in the control group (P =0.005).Moreover,aa,ab and bb of the HPA-15 allele got 35,8 and 7 cases in the observation group,while there were 47,2 and 1 cases in the control group (P =0.007).Homozygous aa were the most common gene type in the donors of the both groups,and the difference was no statistically significant (P＞0.05).As aa,ab and bb of the HPA-2,3 change,the percent platelet recovery and platelet corrected growth index both decreased (P＜0.05).Conclusion Platelet transfusion refractoriness is related to HPA gene polymorphism,and allele b may be the cause of platelet transfusion refractoriness.