Effects of Compound Biejia Ruangan Tablets Combined with Entecavir Tablets on Liver Function and He-matoidin of Patients with Chronic Hepatitis B Blood Stasis Syndrome / 中国药房

ABSTRACT

OBJECTIVE:To observe the effects of Compound biejia ruangan tablets combined Entecavir tablets on liver func-tion and hematoidin of patients with chronic hepatitis B(CHB)blood stasis syndrome. METHODS:Totally 110 patients with CHB blood stasis syndrome were selected from Neijiang Second People's Hospital,the Affiliated Hospital of Southwest Medical Univer-sity and Yibin First People's Hospital during Jan.-Dec. 2015. They were divided into control group and observation group by strati-fied blocked randomitation,with 55 cases in each group. Control group was given Entecavir tablets 0.5 mg,po,qd;observation group was additionally given Compound biejia ruangan tablets 2.0 g,po,tid. Both groups received treatment for 12 months. TCM syndrome scores,the levels of liver function indexes(AST,ALT,ALP,GGT),serum bilirubin(TBIL,DBIL,IBIL),liver fi-brosis indexes(LN,HA,PⅢP,Ⅳ-C)and Fibroscan(FS)were observed in 2 groups before and after treatment. The occurrence of ADR was recorded. RESULTS:In observation group,2 patients withdrew from the study,and 3 patients of control group with-drew from the study. Before treatment,there was no statistical significance in TCM syndrome scores,the levels of liver function in-dexes,serum bilirubin,liver fibrosis indexes and FS between 2 groups(P>0.05). After treatment,TCM syndrome scores,the lev-els of TBIL,IBIL,LN,HA,PⅢP,Ⅳ-C and FS in 2 groups were significantly decreased,while DBIL level was increased signifi-cantly,and the observation group was significantly better than control group,with statistical significance(P<0.05). The levels of AST and ALT in observation group were decreased significantly,while the levels of ALP and GGT were increased significantly, and the observation group was significantly better than control group,with statistical significance(P<0.05). There was no statisti-prove liver function indexes and bilirubin level,and inhibit liver fibrosis with good safety.