Analysis of 727 ADR Reports of Tinkgo Leaf Extract and Dipyridamole Injection / 中国药房

ABSTRACT

OBJECTIVE:To investigate the characteristics and general rule of ADR induced by Ginkgo leaf extract and dipyri-damole injection,and to provide reference for clinical rational drug use. METHODS:UsingGinkgo leaf extract and dipyridamole injectionADRas subject,the journal articles were retrieved from CJFD during Jan. 1st,2005-Jun. 28th,2016,and then ana-lyzed statistically in respects of gender,age,primary disease,allergic disease,drug use,occurrence time of ADR,organs/systems involved and clinical manifestations. RESULTS:A total of 14 valid articles had been collected,involving 727 patients in total. Meanwhile,female was more than male(57.63% vs. 42.37%)and most of them aged more than 50 years;primary diseases were mainly thromboembolic disease and coronary heart disease;most of ADR happened within 30 min after medication (268 cases, 36.86%). Organs/systems involved in ADR were mainly nervous system (254 cases,28.60%),followed by skin and its appen-dants(228 cases,25.68%),digestive system(187 cases,21.06%);severe ADR could cause anaphylactic shock. There were 18 cases of new severe ADR (2.48%);all ADR cases were recovered,and no death occurred. CONCLUSIONS:It is suggested to strictly control indications,differential diagnosis and treatment,rational drug use,close monitoring through the whole process, maintain a high level of awareness to ADR.