Myeloid-derived suppressor cells-immunotherapy targets in hematological malignancies / 国际肿瘤学杂志
Journal of International Oncology
;
(12): 313-316, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-608431
ABSTRACT
In recent years, the research hot in the field of solid tumor and blood tumor focuses on the myeloid-derived suppressor cells (MDSCs).In tumors, MDSCs not only exert immunosuppression by inhibiting T cell proliferation, destroying the functions of natural killer cells and recruiting regulatory T cells, but also play non-immunosuppression roles in the promotion of angiogenesis and tumor metastasis.All of these hinder the anti-tumor therapy, and particularly affect the curative effect, which are related with a poor clinical prognosis.MDSCs can be used as prognostic markers, which provide new targets for immunotherapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of International Oncology
Year:
2017
Type:
Article
Similar
MEDLINE
...
LILACS
LIS