Progress of microRNA-21 in kidney diseases / 国际儿科学杂志

ABSTRACT

MicroRNA(miRNA) is a class of small noncoding RNA molecules that regulate gene expression by functioning as a post-transcriptional regulatory factor basing on pairing with target mRNA,leading to mRNA cleavage or translation repression,and playing an important role in several fundamental biological and pathological processes.Consequently,nearly every biological process is related to miRNA.MicroRNA-21 is a typical miRNA,which has been found in recent years.It has been shown to participate in the development and prognosis of the pathogenesis of acute kidney injury,IgA nephropathy,renal cell carcinoma and other renal disea ses.Therefore,microRNA-21 may be a new target for the treatment of these diseases in the future.This paper reviews the correlative literature and research development regarding the roles of microRNA-21 in kidney disease,and providing references for diagnosis and treatment of kidney disease in the future.