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Preparation of Breviscapine Microemulsion for Parenteral Injection / 医药导报
Herald of Medicine ; (12): 1024-1028, 2017.
Article in Chinese | WPRIM | ID: wpr-609252
ABSTRACT
Objective To study the prescription and preparation technology of breviscapine microemulsion for parenteral injection,and to evaluate its quality.Methods The prescription was selected and optimized through single-factor test and the pseudo-ternary phase diagram method.The preparation technology was investigated,and the particle diameter,drug content,encapsulation efficiency and haemolyticus were evaluated.Results The prescription composition of breviscapine microemulsion was soybean oilphospholipidHS15PEG400water=10.10.550.556.64 (m/m),with the drug content of 4.01 mg·mL-1,the acquired breviscapine microemulsion exhibited light yellow,uniform and transparent,with average particle diameter of 92.1 nm and encapsulation efficiency of 96.8%.The compatibility test showed no drug precipitation and the preparation was no hemolytic crisis.Conclusion The preparation of breviscapine microemulsion injection is correspond to the main index of parenteral injection.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Herald of Medicine Year: 2017 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Herald of Medicine Year: 2017 Type: Article