Rediscover the Importance of Nitrofuratoin in the Treatment of Uncomplicated Urinary Tract Infection / 医药导报

ABSTRACT

Objective To estimate the value of nitrofuratoin in uncomplicated urinary tract infection by examining antimicrobial resistance of Escherichia coli (E.coli) strains isolated from the patients.Methods The antimicrobial susceptibility information was collected from two projects an antimicrobial survey of clinical urine specimens in 20 hospitals in 15 provinces during 2004-2012 and CHINET Antimicrobial Resistance Surveillance Program during 2005-2014.Then the clinical consumption of nitrofuratoin was analyzed according to the data of sample hospitals from 6 cities of Yangtze River system between 2011 and 2015.Results The antimicrobial susceptibility of E.coli strains showed that the resistance rate to cephalosporins and fluoroquinolones were above 50% during the last decade.Meanwhile,the resistance rate to nitrofuratoin was below 10%.Conclusion Nitrofuratoin,which is an old drug in the treatment of urinary tract infection,is famous for its broad-spectrum antimicrobial activity and high sensitivity to ESBLs producing or non-ESBLs producing strains of E.coli.It is efficacious,safe and cost-effective in the treatment to uncomplicated urinary tract infection in women.Therefore,it is highly recommend that rational use of nitrofuratoin in the clinical practice.