The efficacy of amiodarone combined with enalapril in cardioversion of atrial fibrillation and maintenance of sinus rhythm in patients with hypertension and paroxysmal atrial fibrillation / 中国基层医药

ABSTRACT

Objective To observe the efficacy of amiodarone combined with enalapril in cardioversion of atrial fibrillation and maintenance of sinus rhythm in patients with hypertension and paroxysmal atrial fibrillation.Methods 60 patients with hypertension and paroxysmal atrial fibrillation were selected as study objects.They were divided into study group and control group according to the random number table,30 cases in each group.The control group was treated with amiodarone combined with nifedipine,the observation group was given amiodarone combined with enalapril.After 1,3 and 7 days of treatment,the rates of cardioversion of atrial fibrillation were observed.The rates of maintenance of sinus rhythm were observed after 3,6,9 and 12 months of treatment.The left atrial diameter was calculated by echocardiography.The systolic blood pressure (SBP) and diastolic blood pressure (DBP) were detected by blood pressure monitor.Results The rates of cardioversion of atrial fibrillation in the study group and the control group after 3 and 7 days of treatment were 86.67％ and 63.33％,100.00％ and 86.67％,respectively,the differences were statistically significant (all P ＜ 0.05).The rates of maintenance of sinus rhythm in the study group and the control group after 6,9,and 12 months of treatment were 83.33％ and 57.69％,80.00％ and 53.85％,76.67％ and 50.00％,the differences were statistically significant (x2 =4.487,4.368,4.314,all P ＜ 0.05).There were no significant differences in SBP and DBP between the study group and the control group at 3,6,9 and 12 months after treatment (all P ＜0.05).The left atrial diameter of the study group after 12 months of treatment was (36.73 ± 2.66)mm,which was significantly lower than (38.78 ± 2.64)mm in the control group,the difference was statistically significant (P ＜ 0.05) Conclusion Amiodarone combined with enalapril can improve the conversion rate and the rate of sinus rhythm maintenance in patients with hypertension and paroxysmal atrial fibrillation,and effectively control the atrial enlargement and improve the clinical prognosis.