Simultaneous Determination of Two Ingredients in Indometacin and Furazolidone Suppositories by HPLC / 中国药师
China Pharmacist
;
(12): 961-963, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-610145
ABSTRACT
Objective:
To establish an HPLC method for the simultaneous determination of two ingredients in indometacin and furazolidone suppositories.Methods:
The analysis was performed on an XTerra(R) RP18 column (250 mm×4.6 mm, 5 μm) with gradient elution of methanol and 0.01 mol·L-1 potassium dihydrogen phosphate-triethylamine (100∶0.02) at the flow rate of 1.0 ml·min-1.The column temperature was 30 ℃ and the detection wavelength was 263 nm.The injection volume was 10 μl.Results:
The peaks of furazolidone and indometacin were successfully separated.The linear range of calibration curves was 5.12-81.87 μg·ml-1 (r =1.0000) and 3.78-60.45 μg·ml-1 (r =1.0000), respectively.The average recovey was 99.6% (RSD =1.5%, n =6) and 100.3% (RSD =1.6%, n =6), respectively.The limit of quantification (LOQ) was 0.02 μg·ml-1 and 0.05 μg·ml-1, respectively.Conclusion:
The established method is validated to be suitable for the quality control of indometacin and furazolidone suppositories.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacist
Year:
2017
Type:
Article
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