Effects of β-Cyclodextrin from Different Sources on Inclusion Rate of Menthol / 中国药师

ABSTRACT

Objective: To compare the inclusion rate of menthol with β-cyclodextrin (β-CD) from different sources.Methods: β-Cyclodextrin-menthol inclusion complexes were prepared by a grinding method.The inclusion compound was verified by thin layer chromatography (TLC), powder X-ray diffraction (PXRD) and gas chromatography (GC).The optimized conditions of PXRD were as follows the graphite monochromator was Cu Kα, the voltage was 40 kV, the current was 40 mA, the 2θ scanning range was from 3° to 35°, the scanning step was 0.02° and the scanning rate was 5°·min-1.The optimized conditions of GC were as follows an Agilent DB-wax capillary column, the column temperature was 120°, the inlet temperature was 250°, the detector temperature was 250° and the split ratio was 10∶1.Results: The results of TLC and PXRD proved the formation of inclusion complexes.The inclusion rate of menthol with β-CD from home and abroad was 25% and 47.9%, respectively.Conclusion: The method is simple, accurate and rapid, which can be used to determine the inclusion rate of β-CD from different sources.The results show that the inclusion effect of imported β-CD is better than that of domestic β-CD.