Determination of Nipagin Esters and Metronidazole Illegally Added to Chitosan Medical Devices / 中国药师
China Pharmacist
;
(12): 924-927, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-610156
ABSTRACT
Objective:
To determine bacteriostatic drugs nipagin esters and metronidazole illegally added to chitosan medical devices.Methods:
An HPLC method was used with a ZORBAX Eclipse XDB-C18(250 mm×4.6 mm, 5 μm)column.The mobile phase was water and acetonitrile(65∶35).The flow rate was 1.0 ml·min-1.The detection wavelength was 254 nm.The column temperature was 35℃ and the injection volume was 10 μl.Results:
Nipagin esters were detected out in chitosan suppositories and gel.Metronidazole was detected out in chitosan lotion.Conclusion:
The method is simple and fast, which has guiding significance for further comprehensive studies of bacteriostatic drugs illegally added to chitosan medical devices.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacist
Year:
2017
Type:
Article
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