Analysis on effect of blood anti-D antibody detection in infusing RhD positive homotype RBC for patients with RhD negative / 国际检验医学杂志

ABSTRACT

Objective To investigate the anti-D antibody level after infusing homotype RhD positive RBC in the patient with RhD negative.Methods The clinical data in 20 cases of RhD negative infusing homotype RhD positive RBC in our hospital from January 2010 to January 2016 were collected.The anti-D antibody levels before blood infusion and on 10,20,30,90 d after blood infusion and the titers in the patients with RhD positive were analyzed.Results Among 20 cases of RhD negative infusing RhD positive homotype RBC blood,6 cases were RhD positive within 90 d after blood infusion,in which the RhD positive rates were 25%(3/12) in male and 37.5%(3/8) in female.The anti-D antibody titers in 3 cases of RhD positive were 35,278 and 508 respectively.Conclusion Infusing RhD positive RBC blood in the patients with RhD negative can stimulate the immune mechanism,generates the anti-D antibody at RBC surface.Moreover the RBC phenotype in partial patients with RhD negative may change.