Preparation and Pharmacokinetics in Rats of Voriconazole Long-circulation Liposomes / 中国药师
China Pharmacist
;
(12): 820-823, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-610277
ABSTRACT
Objective:
To prepare voriconazole long-circulation liposomes and evaluate the characteristics of pharmacokinetics in rats.Methods:
Voriconazole long-circulation liposomes were prepared by a thin film dispersion extrusion method.The drug release of voriconazole from the long-circulation liposomes was investigated in phosphate buffer solution (PBS) and in rat plasma.The physicochemical properties of the long-circulation liposomes before and after the freeze-drying were studied, such as the particle diameter and the particle shape.The concentration of voriconazole in plasma was determined after tail-vein injection of the long-circulation liposomes in rats.Results:
The mean particle size of voriconazole long-circulation liposomes was (192.1±49.3)nm with homogeneous small spherical morphology as seen under a transmission electron microscope.Voriconazole was released in a sustained manner in PBS while much faster in plasma from the long-circulation liposomes.The t1/2 and AUC0-t of the long-circulation liposomes was respectively 2.17 and 2.31 times higher than that of voriconazole injection.Conclusion:
Long-circulation liposomes prolong the circulation time and increase the bioavailability of voriconazole.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacist
Year:
2017
Type:
Article
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