Diagnostic Value of Serum miR-122,ALT and HBV-DNA in Patients with Chronic Hepatitis B / 现代检验医学杂志

ABSTRACT

Objective To explore the clinical significance of serum miR-122,ALT and HBV-DNA in patients with chronic hepatitis B(CHB).Methods 900 patients of CHB were selected in Zaozhuang Mining Group Hospital from January 2014 to January 2016,and the serum levels of miR-122,ALT and HBV-DNA were detected,and analysed the relevance among the three and chronic hepatitis B.Results Serum markers of hepatitis B test showed that the HBV-DNA load in patients with chronic hepatitis B or early hepatitis infection was significantly higher than that of other patients (F=12.355,P=0.000),and the ALT content in patients with CHB was significantly higher than that of other patients (F=24.654,P =0.000).There was no significant correlation between ALT and HBV-DNA and HBV-M pattern.With the increase of HBV load,the proportion of hepatitis B patients with ALT ＞ 80 U/L increased gradually within limits (P＜0.05).Correlation analysis showed that ALT content was positively correlated with HBV loading (r=0.919,P =0.034).With the increase of HBV load,the level of serum miR-122 in patients with CHB was gradually increased (F=1463.435,P=0.000).Correlation analysis showed that serum miR-122 was positively correlated with HBV (r=0.975,P=0.012).Conclusion There was a correlation between serum miR-122,ALT and HBV-DNA in patients with CHB.The three indicators have good sensitivity and specificity in the diagnosis of CHB,so can use the three joint detection in the diagnosis in patients CHB,in order to improve the diagnostic accuracy and help patients better treatment.