Evaluation of the effect of neonatal hepatitis B vaccine and the prevention of low and no responders / 中国生化药物杂志

ABSTRACT

Objective To evaluate the immunological effect of neonatal hepatitis B vaccine and to prevent the immunization effect of low and no responders. Methods A total of 1,200 infants were selected from Yantai City, Shandong Province. All the infants were immunized for the first time after birth, and were inoculated with brewer's yeast hepatitis B vaccine 5μg. The venous blood of the infant was taken to separate the serum and the geometric mean concentration of anti-HBs in serum by using chemiluminescent microparticle immunoassay. Of which 128 cases were low, no response were immunized again 71 cases were treated with brewer's yeast hepatitis B vaccine 5μg and 57 cases were inoculated with 10%Hansenula hepatitis B vaccine again and again, three times. The results of the re-immune were evaluated . Results There were 80 cases (62.5%) wtith normal response, 23 cases (17.9%) with high response, 22 cases (17.2%) with low response, 3 cases (2.3%) with no response The immunization response rate of HBsAg positive in fathers and mothers was significantly lower than that in county, city and above, and the fathers' mother HBsAg was negative. There was no significant difference in the positive rate of antibody transfection between the first and the third of the above two yeasts, but the geometric mean concentration of anti-HBs was significantly lower for both vaccines, and the brewer's yeast vaccine was significantly lower. Conclusion The immune response rate of hepatitis B vaccine in children with HBsAg-negative mothers at the county, municipal and above hospitals is relatively high. Compared with the brewer's yeast vaccine, the effect of the hepatitis B vaccine is obviously better .