Observation on the effects of calcium dobesilate on serum Hs-CRP, TNF-α levels and kidney function in patients with maintenance hemodialysis / 中国生化药物杂志

ABSTRACT

Objective To explore the use of maintenance hemodialysis patients in the application of calcium dobesilate on serum Hs-CRP and TNF-α and renal function. Methods 86 patients with maintenance hemodialysis admitted from Xiangyang Central Hospital from October 2015 to November 2016 were divided into 43 patients according to the treatment group and 43 patients in each group. The control group Given conventional hemodialysis treatment, the study group on the basis of the control group given calcium benzenesulfonate treatment, and finally the results of the two groups of patients to statistics and summary. Results Before treatment, the difference of BuN, Scr, Hs-CRP and TNF-α between the study group and the control group was not statistically significant. The scores of BuN, Scr, Hs-CRP and TNF-α in the study group and the control group were significantly higher than those in the control group (P<0.05), and the difference was statistically significant (P<0.05). The serum Hs-CRP and TNF-α in the study group were significantly lower than those in the control group (P<0.05). Conclusion Calcium dobesilate can reduce BuN and Scr, improve renal function, reduce Hs-CRP, TNF-α and improve microinflammation. Patient side effects, improve survival, To improve the quality of life.