Effects of Shuxuetong Combined with Shenmai Injection on Serum hs-CRP, SOD and MDA Levels after Reperfusion in Aged Patients with Acute Myocardial Infarction / 中国生化药物杂志

ABSTRACT

Objective Study the effect of Shuxuetong combined with Shenmai injection on serum CPR, SOD and MDA levels in elderly patients with acute myocardial infarction after PCI, and to analyze the main adverse cardiovascular events. Methods Chose 88 patients with PCI from June 2015 to June 2016 in our hospital, they were randomly divided into observation group and control group, 44 cases in each group. The control group was given conventional drug therapy before PCI. On the basis of this, the observation group was treated with Shuxuetong combined with Shenmai intravenous injection before PCI. The treatment of the two groups continued to one week after PCI. Compared the levels of serum malondialdehyde (MDA), superoxide dismutase (SOD) and hypersensitive C-reactive protein (hs-CRP) between the two groups before and after PCI, and compared the levels of coagulation factor, dynamic electrocardiogram, Left ventricular ejection fraction (LVEF) and myocardial infarct size, and compared the incidence of arrhythmia and major adverse cardiovascular events after PCI. Results The levels of serum MDA and hs-CRP in the observation group were significantly lower than those in the control group (P<0.05), the level of SOD was significantly higher than the control group (P<0.05); The level of coagulation factor in the observation group was significantly higher than that in the control group (P<0.05). The myocardial infarct size, the number of ischemic attacks, the decrease of ST segment and the descending time of ST segment were significantly lower than those of the control group (P<0.01). The incidence of MACE was significantly lower in the observation group than in the control group (P<0.05). Conclusion Conventional treatment combined with Shuxuetong combined with Shenmai injection can effectively prevent ischemia-reperfusion injury in elderly patients with AMI, improve cardiac function and reduce the main adverse cardiovascular events after PCI, which reflects the combination of traditional Chinese and western medicine Advantages, worthy of clinical use.