Amplitude of low frequency fluctuation in depressive patients with diurnal rhythm: a resting-state fMRI study / 中华行为医学与脑科学杂志

ABSTRACT

Objective To explore the energy feature of the spontaneous neural activity in depressive patients with diurnal rhythm.Methods Twenty depressive patients with diurnal rhythm,20 depressive patients without diurnal rhythm and 20 gender-,age-,education-matched healthy controls were scanned with 3.0 T MRI Scanner.According to Results of ANOVA,group-wise two sample t-test was completed.The correlation analysis were conducted between ALFF of significant difference brain regions and the score of Hamilton rating scale for depression.Results The brain regions showing significant differences among three groups were located in the right parahippocampal gyrus(MNI18,-36,-9;K=136),left parietal lobe(MNI-54,-45,42;K=86),left cerebellum crus(MNI-84,-60,36;K=86) and right cerebellum crus(MNI9,-78,-36;K=91)(P0.05).Conclusion The diurnal rhythm observed in depression may be associated with aberrant activity of parahippocampal gyrus.