Preliminary study on manufacture process of transdermal patch of nitroglycerin
Pharmaceutical Journal
;
: 15-18, 2003.
Article
in Vietnamese
| WPRIM
| ID: wpr-6116
ABSTRACT
Nitroglycerin, a vasoactive substance, has been used in the treatment of vagina for more than 100 years. To sustain the pharmaceutical effect, doses were administered every 2 hours. Recently the transdermal delivery systems have became popular. Based on eudragit E 100, we combined it with plasticizer (dibutyl sebacate/triethyl citrate), crosslinker (succinic acid), active ingredient (nitroglycerin) and further excipients (e.g. permation enhances ethyl alcohol) to form a self adhesive matrix system for use in nitroglycerin patch. The concentration of nitroglycerin in the patch was determined by HPLC assay
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Adjuvants, Pharmaceutic
/
Chromatography, High Pressure Liquid
/
Nitroglycerin
Language:
Vietnamese
Journal:
Pharmaceutical Journal
Year:
2003
Type:
Article
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