Impact of time interval between radical hysterectomy with pelvic node dissection and initial adjuvant therapy on oncological outcomes of early stage cervical cancer / 부인종양
Journal of Gynecologic Oncology
;
: e42-2017.
Article
in English
| WPRIM
| ID: wpr-61164
ABSTRACT
OBJECTIVE:
To determine the impact of time interval (TI) from radical hysterectomy with pelvic node dissection (RHND) to adjuvant therapy on oncological outcomes in cervical cancer.METHODS:
The study included 110 stage IA2–IB1 cervical cancer patients who underwent RHND and adjuvant therapy. The patients were divided into 2 groups based on the cut-off points of TI of 4 and 6 weeks, respectively. The associations of TI and clinicopathologic factors with oncological outcomes were evaluated using Cox proportional-hazards regression.RESULTS:
The median TI was 4.5 weeks. There were no statistical differences in 5-year recurrence-free survival (RFS) (89.2% vs. 81.0%, and 83.2% vs. 100.0%) or 5-year overall survival (OS) rates (90.9% vs. 97.2%, and 93.2% vs. 100.0%) between patients according to TI (≤4 vs. >4, and ≤6 vs. >6 weeks, respectively). Deep stromal invasion (p=0.037), and parametrial involvement (PI) (p=0.002) were identified as independent prognostic factors for RFS, together with the interaction between TI and squamous cell carcinoma histology (p<0.001). In patients with squamous cell carcinoma, a TI longer than 4 weeks was significantly associated with a worse RFS (hazard ratio [HR]=15.8; 95% confidence interval [CI]=1.4–173.9; p=0.024). Univariate analysis showed that only tumor size (p=0.023), and PI (p=0.003) were significantly associated with OS.CONCLUSION:
Delay in administering adjuvant therapy more than 4 weeks after RHND in early stage squamous cell cervical cancer results in poorer RFS.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Time Factors
/
Carcinoma, Squamous Cell
/
Uterine Cervical Neoplasms
/
Radiotherapy, Adjuvant
/
Epithelial Cells
/
Chemoradiotherapy, Adjuvant
/
Hysterectomy
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Journal of Gynecologic Oncology
Year:
2017
Type:
Article
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