Relationship between preoperative FIB-4 and hepatocellular carcinoma prognosis after curative resection / 中国肿瘤临床
Chinese Journal of Clinical Oncology
;
(24): 498-501, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-612495
ABSTRACT
Objective:
To investigate the correlation between FIB-4 and the clinicopathological characteristics and prognosis of patients with hepatocellular carcinoma (HCC) after curative resection.Methods:
From January 2009 to December 2012, the clinicopathological and follow-up data of 245 patients with HCC after curative resection were retrospectively studied. Their survival was calculated using the Kaplan-Meier method. The Cox proportional hazard regression model was used for the multivariate analysis.Results:
According to FIB-4 index, patients were divided into two subgroups FIB-4Ⅰ(≤3.25) and FIB-4Ⅱ(>3.25). FIB-4 could predict liver cirrhosis severity (Ishak grade, Grade 1-5 vs. Grad 6, r=0.681, P<0.001). It was associated with liver function such asaspartate transaminase (P<0.001)、total bilirubin (P=0.009)、albumin (P=0.001) and platelet count (P<0.001) other than tumor clinicopathologic features. Both univariate and multivariate analysis showed FIB-4 could predict the prognosis of HCC patients (Overall survival P=0.037 and 0.011; Recurrencefree survival P=0.027 and P=0.043, respectively).Conclusion:
The preoperative FIB-4 index could be used as a prognostic marker for the prognosis of HCC after curative hepatectomy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Journal of Clinical Oncology
Year:
2017
Type:
Article
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