Extraction Technology Optimization for Organic Acids in Crataegi Fructus by Central Composite De-sign-response Surface Method / 中国药房
China Pharmacy
;
(12): 2241-2243, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-612503
ABSTRACT
OBJECTIVE:
To optimize the extraction technology for organic acids in Crataegi fructus.METHODS:
Based on sin-gle factor test,using liquid-solid ratio,extraction time and ethanol volume fraction as independent variables,extraction yield of or-ganic acids as dependent variable,central composite design-response surface method was used to optimize the extraction technology of organic acids in Crataegi fructus.RESULTS:
The optimal extraction technology was as follow as liquid-solid ratio of 18.51, adding 75% ethanol,reflux extraction twice,2.0 h each time. Average extraction yield of organic acids in verification test was 5.22%(RSD=2.70%,n=3),with 1.75% relative error of the predicted value(5.13%).CONCLUSIONS:
Optimized extraction technology for organic acids in Crataegi fructus is simple,with good reproducibility and predictability.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
China Pharmacy
Year:
2017
Type:
Article
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