Study of NT-1 in Promoting the Recovery Mechanism in MCAO Model / 现代医院
Modern Hospital
;
(6): 710-712,715, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-612579
ABSTRACT
Objective To explore the study of NT-1 promote recovery mechanisms after cerebral ischemia.Methods 30 ICR mice were equally divided into NT-1 and BSA groups and respectively given NT-1 and BSA injection in the brain.The middle cerebral artery ischemia model was established with suture method.NRSS score and beam-walking test were used to exam the behavior performance after MCAO.Immnuohischemstry was used to evaluate the status of angiogenesis and apoptosis.Results Compared to the BSA group, NT-1 not only reduced the time on the beam-walking but the score of NRSS behavioristices.NT-1 also increased the number of vessels and reduced the number of apoptotic cells.Conclusion NT-1 cerebral injection can promote the recovery by increasing angiogenesis and inhibiting apoptosis.NT-1 is a promise target in the treatment of cerebral ischemia.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Modern Hospital
Year:
2017
Type:
Article
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