Effects of laparoscopic distal gastrectomy on serum IL-2 and IL-4 levels in patients with advanced gastric cancer / 中国基层医药

ABSTRACT

Objective To study the effects of laparoscopic distal gastrectomy on serum interleukin-2(IL-2) and interleukin-4(IL-4) levels in patients with advanced gastric cancer.Methods 142 patients with advanced gastric cancer were randomly devided into the control group(71 cases) and the observations group(71 cases) according to the table.The control group was treated with open surgery,while the observation group was treated with laparoscopy.The operation time,intraoperative blood loss,incision length,number of lymphnode dissection,postoperative pain score,average postoperative hospital stay were recorded in the two groups.The serum IL-2 and IL-4 levels were measured before operation and 24 h,36 h after operation.Results The operation time,intraoperative blood loss,incision length,number of lymph node dissection,postoperative anal exhaust time,postoperative pain score,postoperative hospitalization days of the control group were (141.3±29.7)min,(177.6±26.8)mL,(13.2±2.8)cm,(18.1±2.6),(5.9±1.6)d,(8.5±2) and (15.9±3.3)d,respectively,which of the observation group were (196.4±31.6)min,(100.7±21.3)mL,(5.9±1.6)cm,(17.9±2.8),(3.0±1.1)d,(5.2±1.6) and (10.5±1.9)d,respectively.The operation time of the observation group was significantly longer than that of the control group (t=3.264,P0.05).In the control group,the IL-2 levels of preoperation and 24h,36h,72h postoperation were (87.26±4.63)μg/mL,(51.26±3.31)μg/mL,(62.18±4.08)μg/mL,(71.66±3.81)μg/mL,respectively,which of the observation group were (87.01±3.91)μg/mL,(69.82±3.09)μg/mL,(80.14±4.24)μg/mL and (82.26±3.47)μg/mL,respectively.There was no significant difference in serum IL-2 level between the two groups (t=0.548,P>0.05).The postoperative serum IL-2 was significantly reduced,and the serum IL-2 levels of postoperative 24h,36h,72h of the observation group were significantly higher than those of the control group (t=3.926,4.867,3.019,all P0.05).Postoperative serum IL-4 level was significantly reduced,and the serum IL-4 level of postoperative 24h,36h,72h of the observation group were significantly higher than those of the control group (t=4.012,4.114,3.726,all P<0.05).Conclusion Laparoscopic distal subtotal gastrectomy for advanced gastric cancer patients has less trauma,less immunosuppression,it is conducive to postoperative recovery.