Study on the relationship between RBP4,Hcy and diabetic retinopathy / 国际检验医学杂志

ABSTRACT

Objective To investigate the changes and correlation of retinol binding protein 4 (RBP4) and homocysteine (Hcy) levels in patients with diabetic retinopathy (DR).Methods 124 cases selected from the department of endocrinology admissions of patients with type 2 diabetes,divided into diabetic patients with non proliferative retinopathy group (NPDR group,40 cases),diabetes with value-added retinopathy group (PDR group,41 cases),diabetic retinopathy group (NDR group,n=43) and healthy volunteers group (NC group,40 cases),fasting venous blood indexes,correlation and multiple regression analysis in parallel.Results The RBP4,Hcy in PDR group were higher than NPDR group and NDR group,the difference was statistically significant(P<0.05);The RBP4 and Hcy in NPDR group were higher than NDR group,the difference was statistically significant(P<0.05);RBP4 and FPG,HbA1c,TC,TG,LDL-C and Hcy showed a positive correlation(P<0.05),and HDL-C showed a negative correlation(P<0.05),FPG and Hcy;HbA1c,TC,TG,LDL-C and RBP4 showed a positive correlation(P<0.05),and HDL-C showed a negative correlation(P<0.05);multi factor regression analysis,diabetic retinopathy and Hcy,RBP4 and HbA1c showed a positive correlation(P<0.05).Conclusion The levels of Hcy and RBP4 in patients with DR are highly expressed,and gradually increase with the progression of the disease,which is positively related to the occurrence and development of DR,and can be used as an important risk factor.