Understanding of radiation enteritis and its possible pathogenic mechanism / 中华放射肿瘤学杂志

ABSTRACT

Radiation enteritis significantly affects the quality of life in the patients receiving radiotherapy due to pelvic tumor.As an intestinal inflammation related to radiotherapy, radiation enteritis is an inflammation of the mucous membrane in nature based on some basic research.Studies demonstrate that programmed necroptosis might play a role in the development of inflammatory bowel disease;therefore, as a subtype of inflammatory bowel disease, programmed necroptosis also might play a role in the development and progression of radiation enteritis.This paper aims to review the studies about the nature and pathogenic mechanism in order to contribute to the treatment of radiation enteritis and improve patients'' quality of life.