Synthesis and antiproliferative activities of 5H-benzo[b] carbazole-6,11-diones / 中国药科大学学报
Journal of China Pharmaceutical University
;
(6): 157-166, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-613409
ABSTRACT
A series of 5H-benzo[b] carbazole derivatives were synthesized to find new TopⅡ inhibitors.The substitution pattern at C-9 was discussed.All 16 compounds were tested for their antiproliferative activities against 4 tumor cell lines (SMMC-7721,S1,HCT116,and HeLa) by sulforhodamine B assay.Four compounds were found to inhibit the proliferation of all tested cell lines.And compound 10e displayed the best antiproliferative activity against all 4 tested cell lines with IC50 values of 5.06,4.50,5.29,and 6.32 μmol/L,respectively.
Full text:
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Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of China Pharmaceutical University
Year:
2017
Type:
Article
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