Efficacy of mifepristone combined with misoprostol in terminating scar uterine pregnancy / 中国生化药物杂志

ABSTRACT

Objective To study the efficacy and safety of mifepristone combined with the end of pregnancy in the treatment of uterine scar pregnancy.Methods50 cases of the experimental group in our hospital from February 2014 to December 2016 during the termination of pregnancy uterine scar pregnancy in this study in the research process, no scar uterine pregnancy were 50 as the control group in the process of research.The experimental group and the control group patients were given mifepristone treatment, oral use, patients in the drug treatment of third days should be carried out taking the drug misoprostol experiment, fasting medication, placed in the posterior fornix of vagina.Comparative analysis of the experimental group and the control group of patients with treatment effects and adverse reactions.ResultsAfter a period of treatment, the experimental group and the control group, the time of vaginal discharge and the amount of vaginal bleeding and uterine contractions were no significant difference in the time, not statistically significant.The experimental group of 50 patients, the number of effective treatment for 47 cases, the effective rate was 94%.The control group of 50 patients, the number of effective treatment for the treatment of 48 cases, the effective rate was 96%.As a result, there was no significant difference between the experimental group and the control group in the treatment efficacy, which was not statistically significant (P>0.05).The incidence of adverse reactions in the experimental group was 10%, and the incidence of adverse reactions in the control group was 8%.As a result, there was no significant difference between the experimental group and the control group in the incidence of adverse reactions, which was not statistically significant.ConclusionMifepristone combined with carboprost suppository in the treatment of uterine scar end effect is good, high treatment efficiency, reduce the incidence of adverse reaction, high safety, can reduce the patients caused by trauma to a great extent, is further applied in clinical significance.