Clinical observation of radical postoperative pain oxycodone controlled intravenous analgesia for the treatment of cervical cancer / 中国生化药物杂志

ABSTRACT

Objective To observe the curative resection of oxycodone hydrochloride controlled intravenous analgesia pump after treatment of cervical cancer (patient-controlled-intravenous analgesia, PCIA) and the adverse effect of pain.Methods March 2016 to February 2017 undergoing open radical resection of cervical cancer patients with 108 cases, were randomly divided into observation group(n=54) and control group(n=54), the observation group was given oxycodone hydrochloride injection intravenous patient-controlled analgesia pump, the control group were treated with Sufentanil Citrate Injection patient-controlled analgesia pump, anal exhaust time, contrast two groups of patients with adverse drug reactions and postoperative 6h, 12h, 24h, 48h (NRS Numeric Rating Scale, NRS) pain score.ResultsPain score 12h observation group compared with the control group NRS pain score (P<0.05), with statistical difference, 6h, 24h, 48h time group NRS pain scores haveno statistical difference.Adverse reactions in the observation group, 7 cases of nausea, vomiting in 6 cases, 2 cases of hypotension;control group 16 cases of nausea and vomiting in 14 cases, 1 cases of hypotension, 1 cases of skin allergy, 1 cases of dizziness, adverse reaction rates were significantly higher than the observation group (P<0.05), the difference was statistically significant.Exhaust time observation group (2.93±0.63) days, the control group (2.76±0.61) days, no statistical significance.ConclusionOxycodone controlled intravenous analgesia pump for analgesia in patients with radical resection of cervical carcinoma after open surgery, with less adverse reactions.