Efficacy and safety of atorvastatin calcium combined with aspirin in the treatment of coronary heart disease / 中国基层医药

ABSTRACT

Objective To investigate the efficacy and safety of atorvastatin calcium combined with aspirin in the treatment of coronary heart disease.Methods 180 patients with coronary heart disease were randomly divided into observation group and control group according to the random number table method from January 2011 to January 2016,90 cases in each group.On the basis of the treatment of oxygen therapy,the treatment of metoprolol,valsartan,the control group was treated with aspirin (100mg,1 time/d),and the observation group was treated with atorvastatin (20mg,1 time/d) + aspirin (100mg,1 time/d).The efficacy,blood lipid levels,the level of high-sensitivity C-reactive protein (hs-CRP),nitric oxide (NO) and endothelin-1 (ET-1) were compared between the two groups.Results The total effective rate of the observation group was significantly higher than that of the control group (86.7% vs.68.9%,x2=8.229,P0.05).Conclusion Atorvastatin calcium combined with aspirin has good effect in the treatment of coronary heart disease,and has high security.