Allogeneic bone versus autologous iliac bone graft for scoliosis / 中国组织工程研究

ABSTRACT

BACKGROUND: Scoliosis is a kind of commonly seen spinal deformity, and as a recommended therapy,autologous bone graft has obtained satisfactory outcomes, but there are still some limitations.OBJECTIVE: To observe the therapeutic effect of allogeneic bone and autologous iliac bone graft for scoliosis.METHODS: Ninety-two patients with scoliosis received posterior pedicle screw fixation and selective spinal fusion46 cases for autologous bone transplantation (control group), and the others for allogeneic bone transplantation (observation group). The clinical indexes, Cobb angle loss rate, bone graft fusion and adverse reactions in the two groups were evaluated postoperatively.RESULTS AND CONCLUSION: The recovery time of the initial body temperature, white cell count and erythrocyte sedimentation rate returned to normal as well as drainage time in the control group were significantly shorter than those in the observation group (P 0.05). The bone graft fusion rate showed no significant difference at 3, 6, 13 and 24 months postoperatively (P > 0.05). The screw loosening, ruptured and broken robs occurred neither in control group nor in the observation group. The incidences of pain and infection in the control group were significantly higher than those in the observation group (P < 0.05). These findings suggest that both allogeneic bone and autologous iliac bone graft can achieve satisfactory efficacy in the treatment of scoliosis.