DNA methylation and histone modifications is involved in arsenic induced carcinogenesis / 中华地方病学杂志

ABSTRACT

Epidemiological studies have indicated that a high prevalence rate of lung cancer,bladder cancer and liver cancer in the arsenic exposure population.As a weak mutagenic carcinogen,the mechanism of arsenic induced carcinogenesis has not yet been fully elucidated.In recent years,more and more studies have showed that the DNA methylation and the alternation of histone modification patterns might be involved in the carcinogenesis induced by arsenic.Therefore,in this paper we reviewed the alternation of DNA methylation and histone modification patterns,such as histone acetylation,histone methylation and histone phosphorylation,induced by arsenic exposure;and we also reviewed the role of histone modification and DNA methylation in the process of arsenic carcinogenesis.