A Meta-analysis of the relationship between ACE gene L/D polymorphism and vitiligo / 中国医师杂志

ABSTRACT

Objective To investigate the relationship of angiotensin converting enzyme (ACE I/D) gene I/D polymorphism with vitiligo.Methods PubMed,the Cochrane Library,China academic journal full-text database and VIP database and Wan fang database were searched according to the inclusion and exclusion criteria,and the quality of included studies was assessed.The data were quantitatively analyzed by Stata 12.0 software.Results Nine articles were included.Meta analysis results showed that the susceptibility of vitiligo difference was statistically significant in the total population of ACE I/D genotype (DD + II)vs.DI (OR=0.759,95％ CI0.643 ～0.896,P=0.001),the (DD+DI) vs.II (OR=1.523,95％ CI1.153 ～2.011,P =0.003).The genotype subgroup analysis showed the D vs.I (OR =1.381,95％ CI1.054 ～1.810,P=0.019),DDvs.II (OR=1.830,95％ CI1.110～3.017,P=0.018),(DD+ II) vs.DI (OR=0.814,95％ CI0.667 ～0.994,P=0.043),and the (DD+ID) vs.II (OR=1.690,95％ CI1.147 ～2.489,P =0.008) in Asian.The difference was statistically significantly related to vitiligo.Arab genotype (DD + II) vs.DI (OR =0.545,95％ CI0.354 ～ 0.840,P =0.006) was associated with vitiligo occurrence.Begg's inspection publication bias analysis showed all genetic types did not exist any publication bias.Conclusions The ACE gene I/D polymorphism may be associated with vitiligo susceptibility.