Analysis of Risk Factors for Nosocomial Infections and Drug Resistance of Pathogens in 480 Patients with Craniocerebral Injury / 医药导报

ABSTRACT

Objective To investigate the risk factors for nosocomial infections and analyze pathogens drug resistance in patients with craniocerebral injury so as to provide scientific basis for clinical precaution and treatment.Methods A retrospective survey was conducted to collect the clinical data of 480 patients with craniocerebral injury including the gender,age and therapeutic process of patients by medical history,for analyzing the related factors causing nosocomial infections via SPSS 18.0 software.Then,the results of bacterial culture and drug sensitivity test were recognized to analyze drug resistance of pathogenic bacteria.Results The nosocomial infections occurred in 100 of 480 patients with craniocerebral injury,with an infection rate of 20.83%.The univariate analysis indicated that the risk of nosocomial infections was associated with age,tracheal tube,deep vein catheterization,the length of tracheotomy,the length of hospital stay,diabetic mellitus and hemoglobin ≤110 g·L-1 (P<0.05).Totally 191 strains of pathogens have been isolated,including 118 (61.8%) strains of gram-negative bacteria,46 (24.1%) strains of gram-positive bacteria and 27 (14.1%) strains of fungi.The Acinetobacter baumannii,Pseudomonas aeruginosa,Klebsiella pneumoniae,Escherichia coli were dominant among the gram-negative bacteria,and the drug resistance rates of them to cefazolin and cefotaxime were high;The Staphylococcus aureus,Enterococcus faecalis and Staphylococcus were the major species of the gram-positive bacteria,which were insensitive to penicillin and clindamycin;the Candida albicans was the major species of the fungi.Conclusion The incidence of nosocomial infections is high in the patients with craniocerebral injury,which is accociated with many risk factors.Therefore,it is necessary to strengthen the control of the risk factors so as to effectively reduce the incidence of nosocomial infections.