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Loss of Liver Fatty Acid Binding Protein Expression in Hepatocellular Carcinomas is Associated with a Decreased Recurrence-Free Survival
Journal of Liver Cancer ; : 30-35, 2015.
Article in English | WPRIM | ID: wpr-61463
ABSTRACT
BACKGROUND/

AIMS:

Loss of liver fatty acid binding protein (LFABP) expression by immunohis-tochemistry is a useful marker for the identification of hepatocyte nuclear factor 1alpha (HNF1alpha)-inactivated hepatocellular adenomas; however, the expression status of LFABP in hepatocel-lular carcinomas (HCCs) is still unclear. We aimed to investigate the expression status of LFABP in HCCs and examine the clinicopathological characteristics of LFABP-negative HCCs.

METHODS:

Immunohistochemical stains LFABP, K19 (mouse monoclonal, Dako, Glostrup, Den-mark) and EpCAM (mouse monoclonal, Calbiochem, Darmstadt, Germany) were performed on tissue microarray sections from 188 surgically resected HCCs, and the association between LFABP expression status and the clinicopathological features, survival and "stemness"-related marker expression status were analyzed.

RESULTS:

Loss of LFABP expression was noted in 30 (16%) out of 188 HCCs. LFABP-negative HCCs were associated with a decreased recurrence-free survival (LFABP-negative 17.0 +/- 4.84 months [95% confidence interval [CI] 7.5-26.5 months] versus LFABP-positive 51.0 +/- 8.7 months [95% CI 34.0-68.0 months]; P=0.004). HCCs with LFABP expression loss were more frequently larger and showed more frequent vascular invasion, although not statistically sig-nificant; and an inverse correlation was seen between LFABP expression and K19 expression status (P=0.001).

CONCLUSIONS:

Loss of LFABP expression is seen in HCCs, and is associated with a decreased recurrence-free survival.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Adenoma, Liver Cell / Carcinoma, Hepatocellular / Coloring Agents / Fatty Acid-Binding Proteins / Hepatocyte Nuclear Factor 1-alpha / Liver Type of study: Prognostic study Language: English Journal: Journal of Liver Cancer Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Adenoma, Liver Cell / Carcinoma, Hepatocellular / Coloring Agents / Fatty Acid-Binding Proteins / Hepatocyte Nuclear Factor 1-alpha / Liver Type of study: Prognostic study Language: English Journal: Journal of Liver Cancer Year: 2015 Type: Article