Effects of Deoxyschisandrin on Hemorrheology and Coagulation Function in Ulcerative Colitis Mice / 现代生物医学进展

ABSTRACT

Objective:To observe the effects of Deoxyschisandrin on hemorrheology and coagulation function in ulcerative colitis (UC)mice.Methods:Trinitrobenzenesulfonic acid (TNBS)induced UC mice model was prepared.And then UC mice were randomly divided into model group,positive control group,high,medium,and low dose groups of deoxyschisandrin (80,40,20mg/kg),and in addition,a normal control group was set up.There were 10 mice in each group respectively.UC mice were intragastricly administrated with different concentration of deoxyschisandrin in medication group,or with equal volume distilled water in normal group or model group,respectively.The blood viscosity was determined by blood rheometer,and the bleeding time (BT)and the clotting time (CT)were also observed through the methods of tail cutting and blood coagulation in glass plates accordingly.Results:Compared with model group,the BT (P ＜ 0.01)and CT (P ＜ 0.05)were significantly prolonged,and the blood viscosity was decreased obviously (P ＜ 0.05) in UC mice after administrated with different concentration deoxyschisandfin for 14 days.And the effects in high dose group were strongest and similar to those in the positive group.Conclusions:Deoxyschisandrin can improve hemorrheology and coagulation function in UC mice.