Effects of Phentolamine and Dopamine Combined with Cardiopulmonary Resuscitation on Sudden Cardiac Arrest / 现代生物医学进展

ABSTRACT

Objective:To study the effects of phentolamine and dopamine combined with cardiopulmonary resuscitation on the patients with cardiac arrest.Methods:60 patients with cardiac arrest who were treated from February 2015 to April 2016 in our hospital were selected and divided into the control group and the observation group according to different treatment methods.The control group was treated with routine treatment.while the observation group was treated with phentolamine and dopamine based on the control group.The changes ofcTnI,CK,CK-MB levels,MDA,SOD concentration and hemodynamics were observed before and after treatment.Results:After treatment,the total mortality was 20％ in the observation group,which was significantly lower than that of the control group (33.33％,P＜0.05).The levels of cTnI in the observation group were significantly lower than those of the control group at 2 h and 24 h after the cardiopulmonary resuscitation(P＜0.05).After the cardiopulmonary resuscitation,the serum levels of CK and CK-MB in the observation group were significantly lower than those in the control group (P＜0.05).The concentration of MDA and SOD in the observation group were significantly higher compared with the control group [(1.86± 1.65) μg/L vs(3.81± 1.24) μg/L、(6.58± 0.95)μg/L vs(3.74± 0.56) μg/L](P＜0.05).After the cardiopulmonary resuscitation,the MAP value of observation group was significantly higher than that of the control group (P＜0.05).The CO value and CI value of observation group were significantly increased from the 6th day to the control group (P＜0.05),and the PCWP values of observation group were significantly lower than those of the control group (P＜0.05).Conclusion:Phentolamine combined with dopamine could effectively improve the cardiac hemodynamics and prognosis of patients with cardiac arrest,reduce the myocardial injury and enhance the survival with high safety.