The Clinical Value of Combined Detection of PCT and IL-6 in the Differential Diagnosis Septic and Non-septic SIRS in ICU / 现代生物医学进展

ABSTRACT

Objective:To explore the value of combined detection of PCT and IL-6 in differential diagnosis SIRSin ICU patients.Methods:100 patients with ICU admitted to our hospital from 2013 to 2016 were choosen,including 61 cases with non septic SIRS and 39 cases with sepsis,and 50 healthy persons over the same period were selected as control,and they were divided into non-septic group,sepsis group and control group.The levels of serum PCT and IL-6 were detected by electrochemiluminescence assay,and took PCT of 2 g/L and IL-6 of 50 ng/L for the critical value to identify non infectious SIRS and sepsis,to evaluate the clinical diagnostic value of combined detection.Results:The maximum values of PCT and IL-6in the non-septic group respectively were 0.91 ± 0.54 μg/L and 62.77± 11.75 ng/L,in the septic group respectively were 24.49± 5.00 μg/L and 1542.69± 361.66 ng/L,in the control group respectively were 0.08± 0.06 tμg/L and 3.68± 1.11 ng/L,the maximum values of PCT and IL-6 in the non-sepsis group and the sepsis group were significantly higher than control group (P＜0.05).Compared with the non-septic group,the maximum valuesin sepsis group were significantly increased (P＜0.05).The proportions of PCT ＞ 2 g/L and IL-6 ＜ 50ng/L in the non-septic group respectively were 21.31％ and 65.57％,in the septic group respectively were 92.31％ and 87.18％,the proportions of PCT＞2 g/L,IL-6＜50 ng/L in the sepsis groupwere significantly higher chan those in the non-septic group (P＜0.05).The positive predictive values,sensitivity and specificity of PCT were higher than IL-6,the positive value,specificity of combined detection was higher than IL-6 and PCT,while the sensitivity of combined detection was higher than IL-6,P＜0.05.Conclusions:Combined detection of PCT and IL-6 is helpful for differential diagnosis of sepsis and non-septic SIRS.