Correlation among serum UA, Hcy levels and coronary disease severity in aged patients with coronary heart disease / 心血管康复医学杂志

ABSTRACT

Objective:To explore correlation among serum uric acid (UA), homocysteine (Hcy) levels and coronary disease severity in aged patients with coronary heart disease (CHD).Methods: A total of 98 aged CHD patients, who were treated in our department from Jan 2014 to Dec 2015, were selected.According to Gensini score, they were divided into low score group (≤30 scores, n=32), medium score group (30~60 scores, n=33) and high score group (≥60 scores, n=33).Serum concentrations of UA and Hcy, coronary stenosis degree calculated by Gensini score and coronary intimal atherosclerotic plaque proportion calculated by Sullivan score were measured and compared among three groups.Results: Compared with low Gensini score group, there were significant rise in serum concentrations of UA [(207.51±79.57) μmol/L vs.(324.12±81.36) μmol/L vs.(454.32±99.15) μmol/L] and Hcy [(10.32±6.84) μmol/L vs.(19.95±7.69) μmol/L vs.(28.92±7.85) μmol/L] in medium score group and high score group, and those of high score group were significantly higher than those of medium score group, P<0.05 or <0.01.Spearman rank correlation analysis indicated that serum UA concentration was significant positively correlated with serum Hcy concentration (r=0.557, P=0.042);Gensini score and Sullivan score were significantly positive correlated with serum concentrations of UA and Hcy in CHD patients (r=0.559~0.894, P<0.05 or <0.01).Conclusion: Coronary disease severity is significant positively correlated with serum concentrations of UA and Hcy in aged CHD patients.Their combined detection may have better effect, which is worth extending.