Effect ofKudiezi injection combined with rosuvastatin on patients with acute cerebral infarction / 国际中医中药杂志

ABSTRACT

Objective To investigate the clinical effect ofKudiezi injection combined with rosuvastatin on patients with acute cerebral infarction(ACI).Methods A total of 90 patients with ACI patients of Department of Neurology of our hospital, from March 2015 to June 2016, were randomly divided into treatment group Ⅰ, treatment group Ⅱ and the control group, 30 in each group. The control group was given atorvastatin, the treatment group Ⅰ received rosuvastatin, and the treatment group Ⅱ was adopted Kudiezi injection combined with rosuvastatin. The curative effect was observed, and blood lipid and coagulation function were compared, and daily life ability and nerve function were recorded.Results The curative ratein treatment group Ⅱ (96.7%)was significantly better than that in treatment group Ⅰ (76.7%) and the control group (73.3%) (χ2=6.537,P<0.05). Total cholesterol,three acyl glycerin,low density lipoprotein in treatment group Ⅱ (4.03 ± 0.83 mmol/L, 1.68 ± 0.46 mmol/L, 2.37 ± 0.48 mmol/Lvs. 4.61 ± 0.89 mmol/L, 2.02 ± 0.81 mmol/L, 2.74 ± 0.68 mmol/L and 5.42 ± 0.75 mmol/L, 2.38 ± 0.67 mmol/L, 3.11 ± 0.81 mmol/L) were significantly lower than those in treatment group Ⅰ and the control group (F=21.538, 8.585, 9.092,P<0.05), and those in treatment group Ⅰ was significantly lower than those in the control group (P<0.05).The fibrinogen (2.48 ± 0.37 g/Lvs.2.81 ± 0.46 g/L, 2.95 ± 0.51 g/L), platelet counts[(125.27 ± 11.88)×109vs.(132.13 ± 13.55)×109 and (133.83 ± 13.91)×109] and prothrombin time (17.52 ± 1.94 svs.(16.14 ± 1.62 s, 15.34 ± 1.18 s) in treatment group Ⅱ were significantly lower and higher than those in treatment group Ⅰ and control group (F=8.592, 3.571, 14.139,P<0.05). The scores of Barthel index (85.63 ± 4.10 vs.81.83 ± 3.92, 79.23 ± 4.81) and NIHSS (3.57 ± 1.17 vs. 4.63 ± 1.22, 5.57 ± 1.33) intreatment group Ⅱ were significantly higher and lower than those in treatment group Ⅰand the control group (F=16.873, 19.550,P<0.05), those in treatment group Ⅰ was significantly higher and lower than those in the control group (P<0.05).ConclusionsKudiezi injection combined with rosuvastatin could improve curative effect ,reduce blood lipid, improve coagulation function, improve quality of life and promote recovery of nerve function in patients with acute cerebral infarction.