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Endoscopic Resection for Synchronous Esophageal Squamous Cell Carcinoma and Gastric Adenocarcinoma in Early Stage Is a Possible Alternative to Surgery
Gut and Liver ; : 59-65, 2015.
Article in English | WPRIM | ID: wpr-61574
ABSTRACT
BACKGROUND/

AIMS:

We investigated the clinical outcomes according to the method of treatment in synchronous esophageal and gastric cancer.

METHODS:

Synchronous esophageal squamous cell carcinoma and gastric adenocarcinoma were diagnosed in 79 patients between 1996 and 2010. We divided the patients into four groups according to treatment; Group 1 received surgical resection for both cancers or surgery for gastric cancer with chemoradiotherapy for esophageal cancer (n=27); Group 2 was treated by endoscopic resection with or without additional treatment (n=14); Group 3 received chemoradiotherapy only (n=18); and Group 4 received supportive care only (n=20).

RESULTS:

The median survival times in groups 1 and 2 were 86 and 60 months, respectively. The recurrence rate and mortality were 23% and 48%, respectively, in group 1 and 21% and 4%, respectively, in group 2. The median survival time was 12 months in group 3 and 9 months in group 4. Multivariate analysis showed that age (p<0.001) and treatment group (p=0.019) were significantly associated with death. Compared with group 1, treatment in the intensive care unit (p=0.003), loss of body weight (p=0.042), and decrease in hemoglobin (p=0.033) were worse in group 1.

CONCLUSIONS:

Endoscopic resection for synchronous esophageal and gastric cancer could be considered as a possible alternative to surgery for early-stage cancer.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Stomach Neoplasms / Esophageal Neoplasms / Carcinoma, Squamous Cell / Adenocarcinoma / Survival Analysis / Nutritional Status / Risk Factors / Endoscopy, Gastrointestinal / Combined Modality Therapy / Neoplasms, Multiple Primary Type of study: Etiology study / Risk factors Limits: Aged / Female / Humans / Male Language: English Journal: Gut and Liver Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Stomach Neoplasms / Esophageal Neoplasms / Carcinoma, Squamous Cell / Adenocarcinoma / Survival Analysis / Nutritional Status / Risk Factors / Endoscopy, Gastrointestinal / Combined Modality Therapy / Neoplasms, Multiple Primary Type of study: Etiology study / Risk factors Limits: Aged / Female / Humans / Male Language: English Journal: Gut and Liver Year: 2015 Type: Article