Clinical effect of Shenmai injection and atorvastatin in treating coronary heart disease of chronic heart failure / 中国生化药物杂志

ABSTRACT

Objective To explore clinical effect of Shenmai injection and atorvastatin in treating coronary heart disease of chronic heart failure(CHF). Methods 44 patients with coronary heart disease of chronic heart failure from April 2016 to April 2017 were included in this study as control group. They were treated with conventional symptomatic treatment, and combined with atorvastatin. 44 cases with coronary heart disease patients of chronic heart failure at the same period received as study group, they were treated with Shenmai injection based on the treatment of the control group,compared the curative effect between two groups. Results After treatment intervention,the total effective rate of TCM syndrome of the study group is higher than the control group(P<0.05). Left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter (LVEDD), left ventricular systolic diameter(LVESD) of cardiac function improved significantly better than control group(P<0.05); Serum hypersensitive c-reactive protein (hs-CRP),brain natriuretic peptide(BNP),plasma tumor necrosis factor alpha (TNF alpha) levels, compared with before treatment were significantly lower,and decreased significantly than that of control group(P<0.05). Incidence of adverse reactions was no significant difference between groups. Conclusion Shenmai injection and atorvastatin in treating coronary heart disease of chronic heart failure can achieve significant clinical effect and improve the patients' heart function, high safety, worthy of further popularization and application in clinic.