Inhibitory effect of SM-1 on human liver microsomal cytochrome P450 enzyme / 中国药理学通报
Chinese Pharmacological Bulletin
; (12): 627-629, 2017.
Article
in Zh
| WPRIM
| ID: wpr-615944
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ABSTRACT
Aim To investigate the effect of SM-1 on seven main cytochrome P450(CYP450)in human liver microsomes.Methods Substrate or SM-1 was incubated with human liver microsomes for 30 min in vitro,and divided into control group and experimental group.The effects of SM-1 on the main phase I metabolic enzymes in human liver microsomes was detected by HPLC.Phenacetin,bupropion,paclitaxel,tolbutamide,omeprazole,dextromethorphan,testosterone were investigated as probe drugs.Results Inhibition rate of SM-1 on the classical substrate of human liver microsomal CYP was 0.05%,3.37%,0.08%,2.07%,4.20%,-0.15%and 10.84%,respectively.Conclusions SM-1 may have inhibitory effect on CYP3A4.Attention should be paid to the interaction of clinical drug induced by CYP enzyme inhibition.
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Language:
Zh
Journal:
Chinese Pharmacological Bulletin
Year:
2017
Type:
Article