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Grey matter concentration revealed by voxel-based morphometry in individuals with cognitive vulnerability to depression / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences) ; (12): 667-672, 2017.
Article in Chinese | WPRIM | ID: wpr-616589
ABSTRACT

Objective:

To explore the grey matter concentration in individuals with cognitive vulnerability to depression.

Methods:

Thirty individuals with cognitive vulnerability to depression and thirty age-and gender-matched healthy controls were enrolled in this study,and they were subjected to magnetic resonance imaging (MRI) examination.The grey matter concentration differences were compared between the two groups by using voxel-based morphometry (VBM) following MRI.

Results:

Individuals with cognitive vulnerability to depression showed significantly lower grey matter density in bilateral insular,left cerebellum,right supplementary motor area,and left precentral gyrus than those in the healthy controls,while the healthy controls showed significantly lower grey density in the right inferior frontal gyrus,right middle frontal gyrus,and left cuneus than those in the individuals with cognitive vulnerability to depression.

Conclusion:

Structural brain abnormalities in individuals with cognitive vulnerability to depression might be the neural basis for cognitive vulnerability to depression.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Central South University(Medical Sciences) Year: 2017 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Central South University(Medical Sciences) Year: 2017 Type: Article