Changes of serum TNF-α,IL-1β,IL-10,IL-13,lung ultrastructure and respiratory function in the early stage of pulmonary contusion / 实用医学杂志

ABSTRACT

Objective To investigate the changes of serum TNF-α,IL-1β,IL-10,IL-13,lung ultrastructure and respiratory function in the early stage of pulmonary contusion. Method 16 white rabbits were randomly assigned to lung contusion group and control group. Pulmonary contusion was established. Serum TNF-α,IL-1β, IL-10 and IL-13 level at 1 ,2 ,3 and 4 h after contusion were tested. Respiratory function data was obtained and ultrastructure was observed. Results In the early phase after pulmonary contusion ,the expression of IL-1β and TNF-αincreased while IL-10 and IL-13 decreased continuously. Lung ultrastructure changes included alveolar dam-age and massive erythrocyte sedimentation and inflammatory cell exudation in alveolar cavity. Alveolar ventilation and PO2 decreased significantly,P-AO2 increased continuously and lung compliance reduced. Conclusions In the early phase after pulmonary contusion ,the expression of IL-1β and TNF-α increases while IL-10 and IL-13 de-creases,lung ultrastructure is progressively destructed and lung function is severely damaged.