Early diagnostic value of serum amyloid A combined with C-reactive protein in diagnosis of influenza A in children / 实用医学杂志

ABSTRACT

Objective To evaluate the clinical value of serum amyloid protein(SAA),C-reactive protein (CPR)and SAA/CRP ratio in early diagnosis of influenza A in children. Method SAA,CRP,SAA/CRP ratio and serum white blood cell(WBC)count were measured in 417 children. One hundred and thirty-nine children were diagnosed with Influenza A and were enrolled in the influenza A group ,and the other 278 healthy children were enrolled in the control group from April 2016 to June 2016. The values of the screened biomarkers for diagno-sis of influenza A were assessed by ROC curve analysis. Results Levels of SAA,CRP and SAA/CRP ratio in the influenza A group were significantly higher than those in the control group(P<0.001,respectively). The areas un-der the ROC curve of SAA and SAA/CRP ratio for the diagnosis of influenza A were higher than 0.7(P<0.001). The optimal cut-off values of SAA and SAA/CRP ratio for the diagnosis of Influenza A were 10.500 mg/L and 6.165,respectively. The corresponding sensitivities of the optimal cut-off values for the diagnosis of influenza A were 85.5% and 55.4%,respectively,and the corresponding specificities were 96.8% and 91.4%,respectively. Conclusion Measurement of SAA and SAA/CRP ratio are valuable biomarkers for clinical in early diagnosis of in-fluenza A and SAA has a better diagnostic performance than CRP.