Underlying mechanism of bone marrow mesenchymal stem cells in the repair of radiation-induced hematopoietic injury / 中国组织工程研究
Chinese Journal of Tissue Engineering Research
;
(53): 3407-3413, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-617151
ABSTRACT
BACKGROUND:
Co-transplantation of bone marrow mesenchymal stem cells (BMSCs) and hematopoietic stem cells (HSCs) can improve the survival rate following radiation damage.OBJECTIVE:
To review the mechanisms of BMSCs in hematopoietic reconstitution and immunomodulation after radiation damage.METHODS:
Relevant articles included in the Web of science from 2005 to 2016 were retrieved, and the keywords were mesenchymal stem cells; radiation; radiation injury; hematopoietic stem cells; hematopoietic reconstitution; immunomodulatory in English. Then we sorted and analyzed the articles which were closely related to the theme. RESULTS ANDCONCLUSION:
BMSCs can repair broken DNA double bonds by autophagy and HR/NHEJ pathway; support and protect HSCs by intercellular interactions and paracrine action; and repair radiation-induced hematopoietic injury by inhibiting inflammation and immune responses to maintain HSC homeostasis. Therefore, BMSCs may function as an effective treatment for radiation-induced hematopoietic injury.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Tissue Engineering Research
Year:
2017
Type:
Article
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