Effect of dexmedetomidine on oxidative stress in patients undergoing percutaneous coronary intervention / 临床麻醉学杂志

ABSTRACT

Objective To evaluate the effect of continuous infusion of dexmedetomidine on the oxidative stress in patients undergoing percutaneous coronary intervention (PCI).Methods Fifty patients, with acute myocardial infarction who required for emergency PCI, 39 males, 11 females, aged 47-79 years, weighting 45-83 kg, ASA physical status Ⅲ or Ⅳ, were selected and randomly divided into two groups (n=25 each) using a random number table the control group (group C) and the dexmedetomidine group (group D).In group D, a loading dose of dexmedetomidine 0.5 μg/kg was infused intravenously for 10 min before surgery, and then dexmedetomidine was infused at a rate of 0.2-1.0 μg·kg-1·h-1 during the operation until the end of operation.Patients in group C received the same dose saline in the same way.RASS score was maintained at-2-2 scores in the two groups.Blood samples were collected before the anesthesia induction (T0), at the end of the operation (T1), 6 h after the operation (T2) and 24 h after the operation (T3) to determine the observed changes of PMN, SOD and MDA.The intraoperative adverse reactions including hypotension, bradycardia and hypoxemia were recorded.Results Compared with T0, the number of PMN and the serum concentration of MDA at T1-T3 significantly increased, while effective serum SOD at T1-T3 significantly decreased (P＜0.01 or P＜0.05).The serum concentration of MDA and the number of PMN at T1-T3 in group D were significantly lower than those in group C, while the effective serum SOD was significantly higher than that in group C (P＜0.05).There was no significant difference of intraoperative adverse reactions including hypotension, bradycardia and hypoxemia between the two groups.Conclusion Continuous infusion of dexmedetomidine can decrease oxidative stress thus to alleviate myocardial reperfusion injury.