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A new method for screening latent tuberculosis infection in Beijing army recruits / 军事医学
Military Medical Sciences ; (12): 462-465, 2017.
Article in Zh | WPRIM | ID: wpr-617320
Responsible library: WPRO
ABSTRACT
Objective To investigate the Mycobacterium tuberculosis infections in 2014 among Beijing army recruits, and evaluate a new method for screening latent tuberculosis infections.Methods A total of 194 army recruits were subjected to chest X-ray examination purified protein derivative(PPD) skin test, antibody detection, and interferon gamma release assay(IGRA) by ELISA combined with recombinant protein CFP10-ESAT6 and latent infection protein Rv2628.Results The positive rates of PPD skin test and antibody test were 49.7% and 15.5%, respectively.The latent infection rate of IGRA test was 22.2% in 194 cases after CFP10-ESAT6 stimulation.After stimulation of latent tuberculosis infection(LTBI) with Rv2628, IFN-γ level was significantly higher than that in healthy control group (P0.05).There was no significant difference between antibody negative and positive groups after stimulation by CFP10-ESAT6 and Rv2628 (P>0.05).The area under the ROC curve of Rv2628 diagnosis of tuberculosis infection was 0.84.When Youden index was 0.621,the specificity was 94.7% and sensitivity was 67.4%.ConclusionCombined detection of antigens Rv2628 and CFP10-ESAT6 specific IFN-γ values can be potentially used for differential diagnosis of active or latent tuberculosis infections.
Key words
Full text: 1 Index: WPRIM Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Language: Zh Journal: Military Medical Sciences Year: 2017 Type: Article
Full text: 1 Index: WPRIM Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Language: Zh Journal: Military Medical Sciences Year: 2017 Type: Article